{"created":"2023-05-15T13:45:10.205545+00:00","id":57,"links":{},"metadata":{"_buckets":{"deposit":"c3b11878-fbf1-47d4-87a0-f6495be41e55"},"_deposit":{"created_by":4,"id":"57","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"57"},"status":"published"},"_oai":{"id":"oai:hirosakiuhw.repo.nii.ac.jp:00000057","sets":["5:6:11"]},"author_link":["381","388","393","383","384","389","391","380","390","385","387","394","396","386","392","382","379","395"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effect of polymorphisms in the gamma-glutamyl carboxylase gene GGCX on gamma-carboxylation of osteocalcin and bone mineral density: Comparison of the ucOC/OC ratio by GGCX gene polymorphism"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"GGCX イデンシ タケイ ガ オステオカルシン ノ Glaカ ト コツミツド ニ オヨボス エイキョウ ダイ2ホウ イデンシ タケイ ニヨル ucOC/OCヒ ノ ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"47","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"弘前医療福祉大学紀要"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究の目的は、γ-グルタミルカルボキシラーゼ（GGCX）遺伝子多型が、オステオカルシンのGla化と骨密度に及ぼす影響を検討し、将来、骨代謝異常をきたす慢性疾患を持つ人々に骨量低下や骨粗鬆症の予防のための効果的な栄養指導を行うことである。\n　今回、男女54 人（平均年齢19.4 歳）を対象に調査を行った。GGCX遺伝子（SNP; R325Q, 974G>Ars699664）多型判定試験の結果は、GG型11 人（26.0％）、AA型3 人（6.0％）、GA型40 人（74.0％）で、AA型は、女性のみの検出であった。音響的骨評価値は、AA型が他の遺伝子型に比べて最も低かった。ビタミンKの不足状態を反映する低カルボキシルオステオカルシン（ucOC）の平均値は、GG型8.91 ng/ml（SD = 3.80）、AA型4.30 ng/ml（SD = 2.02）、GA型6.88 ng/ml（SD = 3.40）であった。その原因として、AA型は、ビタミンK摂取量（推定）が少ないことが考えられた。ビタミンKを補酵素とするGGCXの活性の指標となるucOC/OC比は、GG型 1.09（SD=0.30）、AA型 1.41（SD = 0.36）、GA型 1.21（SD = 0.40）であった。これにより、AA型は、ビタミンKが補酵素として効果的に働いていないことが示唆された。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医療福祉大学紀要, 5(1), 2014, p.47-57","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ハセガワ, ヒデタカ"}]},{"nameIdentifiers":[{}],"names":[{"name":"カミグチ, ヒロシ"}]},{"nameIdentifiers":[{}],"names":[{"name":"ムラカミ, ダイスケ"}]},{"nameIdentifiers":[{}],"names":[{"name":"ハセガワ, ユカ"}]},{"nameIdentifiers":[{}],"names":[{"name":"マツキ, ユウキ"}]},{"nameIdentifiers":[{}],"names":[{"name":"マツキ, ヒデアキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Hasegawa, Hidetaka"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kamiguchi, Hiroshi"}]},{"nameIdentifiers":[{}],"names":[{"name":"Murakami, Daisuke"}]},{"nameIdentifiers":[{}],"names":[{"name":"Hasegawa, Yuka"}]},{"nameIdentifiers":[{}],"names":[{"name":"Matsuki, Yuki"}]},{"nameIdentifiers":[{}],"names":[{"name":"Matsuki, Hideaki"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前医療福祉大学紀要編集委員会"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12475995","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-0550","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.6","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"社会医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前医療福祉大学保健学部看護学科"},{"subitem_text_value":"東海大学教育・研究支援センター分子科学部門"},{"subitem_text_value":"弘前医療福祉大学保健学部看護学科"},{"subitem_text_value":"弘前大学医学部附属病院"},{"subitem_text_value":"東海大学医学部付属大磯病院"},{"subitem_text_value":"東海大学健康学部看護学科"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 秀隆"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"神口, 浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 大介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長谷川, 結香"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松木, 勇樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松木, 秀明"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-15"}],"displaytype":"detail","filename":"HirosakiIryoFukushi_5(1)_47.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiIryoFukushi_5(1)_47.pdf","url":"https://hirosakiuhw.repo.nii.ac.jp/record/57/files/HirosakiIryoFukushi_5(1)_47.pdf"},"version_id":"d2d1897f-bb21-4487-b0f7-ef86e4241982"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GGCX遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"ucOC/OC比","subitem_subject_scheme":"Other"},{"subitem_subject":"ビタミンK","subitem_subject_scheme":"Other"},{"subitem_subject":"骨密度","subitem_subject_scheme":"Other"},{"subitem_subject":"GGCX genotype testing","subitem_subject_scheme":"Other"},{"subitem_subject":"undercarboxylated osteocalcin","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin K","subitem_subject_scheme":"Other"},{"subitem_subject":"bone mineral density","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GGCX 遺伝子多型がオステオカルシンのGla化と骨密度に及ぼす影響 : 第二報 GGCX 遺伝子多型によるucOC/OC 比の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GGCX 遺伝子多型がオステオカルシンのGla化と骨密度に及ぼす影響 : 第二報 GGCX 遺伝子多型によるucOC/OC 比の検討"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-30"},"publish_date":"2014-05-30","publish_status":"0","recid":"57","relation_version_is_last":true,"title":["GGCX 遺伝子多型がオステオカルシンのGla化と骨密度に及ぼす影響 : 第二報 GGCX 遺伝子多型によるucOC/OC 比の検討"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-05-15T14:06:40.657626+00:00"}