{"created":"2024-05-31T04:57:47.483519+00:00","id":2000005,"links":{},"metadata":{"_buckets":{"deposit":"da2924c9-dfde-4a06-b395-26230fcc8057"},"_deposit":{"created_by":8,"id":"2000005","owner":"8","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000005"},"status":"published"},"_oai":{"id":"oai:hirosakiuhw.repo.nii.ac.jp:02000005","sets":["5:25:1715926222569"]},"author_link":["1168"],"control_number":"2000005","item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"What is the function of human hair keratins, gifts from Neanderthals? ―Possible involvement in interferon production","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"弘前医療福祉大学・弘前医療福祉大学短期大学部紀要","bibliographic_titleLang":"ja"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"毛は乳腺とともに哺乳類を特徴づける形質である。弘前へアレスラット （HHR） はSprague-Dawleyラットに見出された常染色体劣性の遺伝形式を示す毛のないラットで、メスでは乳腺が早期に退縮する。HHRは哺乳類の機能を調べる上ですぐれたモデルになると考え、我々は、異常がどのような遺伝子の変異によるか解析してきた。本総説ではHHRの原因が5種類のヘアケラチン遺伝子の欠失によること、これまでヘアケラチンは毛と爪だけで発現すると考えられていたが、ヒト乳腺細胞でも発現し、同細胞でのRNA処理に伴うインターフェロンの発現に係る知見を紹介する。現代人（ホモ・サピエンス）がもつへアケラチン遺伝子は、ネアンデルタール人から受け継いだDNAと考えられ、そのようなネアンデルタール人由来のDNAが、現代人の新型コロナウイルス感染症の重症化や軽症化を決める要因になっている最近の知見についても、縄文人のゲノム研究の知見とともに紹介する。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"names":[{"name":"ツチダ, シゲキ","nameLang":"ja-Kana"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Tsuchida, Shigeki","nameLang":"en"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前医療福祉大学 弘前医療福祉大学短期大学部内 紀要編集委員会","subitem_publisher_language":"ja"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12889149","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2435-0915","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"弘前医弘前医療福祉大学保健学部"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土田, 成紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1168","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-31"}],"filename":"HirosakiIryoFukushi_5_1.pdf","filesize":[{"value":"751 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://hirosakiuhw.repo.nii.ac.jp/record/2000005/files/HirosakiIryoFukushi_5_1.pdf"},"version_id":"40bbf4b4-1fe4-4d7b-842f-032c02e0dfd9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヘアケラチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"インターフェロン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"新型コロナウイルス感染症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ネアンデルタール人","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"縄文人","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヘアケラチンは我々に何をもたらしたか ─ インターフェロン産生への関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘアケラチンは我々に何をもたらしたか ─ インターフェロン産生への関与","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"8","path":["1715926222569"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-10"},"publish_date":"2024-06-10","publish_status":"0","recid":"2000005","relation_version_is_last":true,"title":["ヘアケラチンは我々に何をもたらしたか ─ インターフェロン産生への関与"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-06-26T00:21:50.825448+00:00"}