{"created":"2023-05-15T13:45:07.949730+00:00","id":20,"links":{},"metadata":{"_buckets":{"deposit":"ddc52372-3ade-49fa-9c5c-d4ba17545014"},"_deposit":{"created_by":4,"id":"20","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"20"},"status":"published"},"_oai":{"id":"oai:hirosakiuhw.repo.nii.ac.jp:00000020","sets":["5:6:8"]},"author_link":["90","88","89"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アルツハイマー病の固有病変（神経原線塊と老人斑）の発現範囲 : 38歳で発症し25年の経過をとった家族性アルツハイマー病例の病理・解剖学的研究"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"アルツハイマー ビョウ ノ コユウ ビョウヘン シンケイ ゲンセンカイ ト ロウジンハン ノ ハツゲン ハンイ : 38サイ デ ハッショウシ 25ネン ノ ケイカ オ トッタ カゾクセイ アルツハイマー ビョウレイ ノ ビョウリ カイボウガクテキ ケンキュウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"1","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"弘前医療福祉大学紀要"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"AD is a rapidly increasing dementia whose measure for medical and social welfare has been a serious\nsocial problem in Japan. The brain lesions of AD are characterized by 3 main histological changes:\nNFT, SP, and loss of neurons. With the reexamination of an AD case with a 25 year-clinical course as\nan opportunity, the author revealed the maximal range of occurrence of NFT and SP in AD. The results\nshowed that neurons were classi›ed into 3 types: neuron types with NFT-rich, NFT-rare, and NFT-free.\nAs to the pathogenesis of AD brain lesions, it is known that Aβ deposition occurs first and the\noligomers with the highest toxicity develop into proto›brils and ›brils and ›nally form neuritic plaques\nwhich contain degenerated neurites. In addition, Aβ oligomers generated in and around synapses and\ninside neurons are considered to induce cell death due to the toxicity to neurons and glial cells. On the\nother hand, it is believed that by GSK3β which is activated by the overproduction of Aβ inside\nneurons, hyperphosphorylation of tau proceeds and soluble oligomers of tau polymerize to be insoluble\ngranular aggregates, and then become larger insoluble NFT. It is still unclear where tau oligomers or\ngranules associate with Aβ oligomers or proto›brils to develop NFT and Aβ ›brils, respectively, and\nwhat mechanisms play roles to develop NFT in “NFT only tauopathies”. Detailed analyses that\nreveal all of differences between NFT-rich and NFT-free neurons may open a road to pathogenetic\nmechanisms of NFT formation.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医療福祉大学紀要, 2(1), 2011, p.1-14","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ヨシムラ, ノリアキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Yoshimura, Noriaki"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前医療福祉大学紀要編集委員会"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12475995","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-0550","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前医療福祉大学 保健学部医療技術学科"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉村, 教暤"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-15"}],"displaytype":"detail","filename":"HirosakiIryoFukushi_2(1)_1.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiIryoFukushi_2(1)_1.pdf","url":"https://hirosakiuhw.repo.nii.ac.jp/record/20/files/HirosakiIryoFukushi_2(1)_1.pdf"},"version_id":"ad0f7ad2-f4f0-4912-a064-ead004cd6fd5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimerʼs disease","subitem_subject_scheme":"Other"},{"subitem_subject":"neurofibrillary tangles","subitem_subject_scheme":"Other"},{"subitem_subject":"AD","subitem_subject_scheme":"Other"},{"subitem_subject":"NFT","subitem_subject_scheme":"Other"},{"subitem_subject":"senile plaques","subitem_subject_scheme":"Other"},{"subitem_subject":"SP","subitem_subject_scheme":"Other"},{"subitem_subject":"tau","subitem_subject_scheme":"Other"},{"subitem_subject":"Aβ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The occurrence range of proper lesions (neurofibrillary tangles and senile plaques) to Alzheimer’s disease : patho-anatomical study of a familial Alzheimer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The occurrence range of proper lesions (neurofibrillary tangles and senile plaques) to Alzheimer’s disease : patho-anatomical study of a familial Alzheimer"}]},"item_type_id":"3","owner":"4","path":["8"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-12-14"},"publish_date":"2011-12-14","publish_status":"0","recid":"20","relation_version_is_last":true,"title":["The occurrence range of proper lesions (neurofibrillary tangles and senile plaques) to Alzheimer’s disease : patho-anatomical study of a familial Alzheimer"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-05-15T17:04:40.283184+00:00"}