{"created":"2023-05-15T13:45:16.384056+00:00","id":183,"links":{},"metadata":{"_buckets":{"deposit":"b578b724-819d-4a75-a96e-ba028a8eaead"},"_deposit":{"created_by":8,"id":"183","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"183"},"status":"published"},"_oai":{"id":"oai:hirosakiuhw.repo.nii.ac.jp:00000183","sets":["5:6:23"]},"author_link":["1189","178","180","1190","179"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A study of the relationship between the pineal, immune mechanisms and cancer ─ a historical survey 1. Immunocytes in the pineal region and the relationship between the pineal and cancer "}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ショウカタイ　ト　メンエキ　キジョ　ト　ガン　トノ　カンレン　ニ　ツイテノ　ケンキュウ　レキシテキ　テンボウ　ショウカタイ　リョウイキ　ノ　メンエキ　サイボウ　オヨビ　ショウカタイ　ト　ガン　トノ　カンレン"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"弘前医療福祉大学紀要"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1. 松果体と細胞免疫学の研究史等の短い説明の後、星野らによるランゲルハンス細胞の電顕的研究とSteinmanの樹状細胞研究を紹介した。2. 松果体領域のリンパ小節に関するAbeらによる最初の系統的論文に続く一連の研究について説明した。3. 松果体と癌および対癌生体防衛における松果体の役割：1）1967年の剖検癌患者での松果体サイズ増大報告に続き、同様または減少の報告もあった。メラトニン（MEL）とその代謝産物の血中、尿中レベルにも両方向性の結果が報告された。2）1977年の第1 回松果体と癌国際会議で、松果体が腫瘍発生過程に関与する神経内分泌因子の1 つと認識され、研究が急激に活性化された。1982年にTamarkinらはエストロゲン受容体陽性乳癌患者の夜間血中MELの低レベルを報告し、1986 年にBlaskとHillはMELの乳癌細胞へのin vitroでの抑制作用を報告した。Lissoniらは1986年に血中MELレベルが日中でも高い幾つかの癌症例を発見し、続いて松果体が免疫機能に促進作用を及ぼすとの基礎研究結果に基づきMEL投与の臨床研究を開始、一部の癌患者に有効との結果を1988年に報告した。3）1988年の第2 回国際会議では、Quayが分子生物学的腫瘍学におけるメチル基移転機序と松果体の関与について発表した。Kachi T らは、松果体- 副腎髄質関連の実験結果とその腫瘍成長への影響について発表し、また同年の別の国際会議では、癌や種々の疾患剖検例での松果体サイズや癌患者のビデオパピログラフィーによる対光反射の検査結果等について発表した。\n1. Following the brief explanation on research histories of pineal, cellular immunology, etc., EM studies on Langerhans cells by Hoshino and the dendritic cell research by Steinman were introduced. 2. The first systematic study on the lymphoid tissue in the pineal region by Abe et al and a series of following papers were presented and interpreted. 3. Pineal and cancer, and pineal roles in body’s defense mechanisms: 1) Following a paper on pineal size increase in cancer autopsy cases in 1967, papers showing similar or decrease results were reported. Similar bidirectional changes were also reported in blood melatonin or urinary melatonin metabolite levels later. 2) At the first international meeting on the pineal gland and cancer in 1977, the pineal was recognized as one of the neuroendocrine factors that should be studied in relation to oncogenic processes, and thereafter the research activity was accelerated. In 1982, Tamarkin et al reported lower nocturnal plasma melatonin levels in estrogen receptor positive breast cancer patients. In 1986, Blask and Hill reported about in vitro suppressive effects of melatonin on breast cancer cells. Lissoni et al found high melatonin levels in part of cancer patients in 1986, and then based on research results that the pineal exerts facilitatory effects on immune functions, they started a clinical melatonin therapy and reported the effectiveness in part of patients in 1988. 3) In the second international meeting in 1988, Quay presented a paper on transmethylation mechanisms and pineal contributions in molecular oncology. Kachi et al reported about the pineal-adrenomedullary relation and its possible influence on tumor growth. At another international meeting in 1988, Kachi et al presented a paper on pineal sizes in cancer and various other disease autopsy cases, examination results on the pupillary light reflex using video-pupillography in cancer patients, etc","subitem_description_type":"Abstract"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"カチ, タカシ"}]},{"nameIdentifiers":[{}],"names":[{"name":"カチ, ヒトミ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Kachi, Takashi"},{"name":"Kachi, Hitomi"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前医療福祉大学内紀要編集委員会"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12475995","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-0550","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"自宅"},{"subitem_text_value":"東北女子大学家政学部健康栄養学科"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加地, 隆"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加地, 眸"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-15"}],"displaytype":"detail","filename":"HirosakiIryoFukushi_10(1)_1.pdf","filesize":[{"value":"705.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiIryoFukushi_10(1)_1.pdf","url":"https://hirosakiuhw.repo.nii.ac.jp/record/183/files/HirosakiIryoFukushi_10(1)_1.pdf"},"version_id":"c20ed33c-1642-441e-b0b7-5ed31b062d1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"樹状細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"頭蓋内リンパ組織","subitem_subject_scheme":"Other"},{"subitem_subject":"癌患者","subitem_subject_scheme":"Other"},{"subitem_subject":"メラトニン","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経- 副腎髄質系","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"松果体と免疫機序と癌との関連についての研究 ─ 歴史的展望　1. 松果体領域の免疫細胞および松果体と癌との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"松果体と免疫機序と癌との関連についての研究 ─ 歴史的展望　1. 松果体領域の免疫細胞および松果体と癌との関連"}]},"item_type_id":"3","owner":"8","path":["23"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-15"},"publish_date":"2019-04-15","publish_status":"0","recid":"183","relation_version_is_last":true,"title":["松果体と免疫機序と癌との関連についての研究 ─ 歴史的展望　1. 松果体領域の免疫細胞および松果体と癌との関連"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2023-05-15T13:49:38.562700+00:00"}